LYMPHOID NEOPLASIA Regulation of multiple myeloma survival and progression by CD1d
نویسندگان
چکیده
1Department of Haematology, Imperial College Healthcare National Health Service (NHS) Trust, Hammersmith and St Mary’s Hospital, Imperial College London, London, United Kingdom; 2Department of Haematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece; 3Department of Histopathology, Imperial College Healthcare NHS Trust, Hammersmith and St Mary’s Hospital, Imperial College London, London, United Kingdom; and 4Department of Haematology and Medical Research, 251 General Air Force Hospital, Athens, Greece
منابع مشابه
Regulation of multiple myeloma survival and progression by CD1d.
Down-regulation of conventional human leukocyte antigen (HLA) class I and II molecules from the surface of tumor cells is an important mechanism for tumor immune evasion, survival, and progression. Whether CD1d, a nonconventional, glycolipid-presenting HLA class I-like molecule instructing the function of the immunoregulatory invariant NKT cells can affect tumor cell survival is not known. Here...
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Background: Multiple myeloma (MM) is a plasma cell disorder characterized by presence of monoclonal protein in serum or urine or both, increased bone marrow plasma cells, osteolytic lesion, hypercalcemia, and anemia. Several combination regimens are commonly recommended for treatment of multiple myeloma. The present study aimed at determining the characteristics and outcomes of patients with mu...
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CCAAT/enhancer-bindingprotein (C/EBP ), also known as nuclear factor–interleukin-6 (NF-IL6), is a transcription factor that plays an important role in the regulation of growth and differentiation of myeloid and lymphoid cells. Mice deficient in C/EBP show impaired generation of B lymphocytes. We show that C/EBP regulates transcription factors critical for proliferation and survival in multiple ...
متن کاملRole of Suppressed Immunoglobulins in Outcome of Patients With Multiple Myeloma
Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...
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Despite the development of novel treatments in the past 15 years, many blood cancers still remain ultimately fatal and difficult to treat, particularly acute myeloid leukaemia (AML) and multiple myeloma (MM). While significant progress has been made characterising small-scale genetic mutations and larger-scale chromosomal translocations that contribute to the development of various blood cancer...
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تاریخ انتشار 2009